The crosstalk between N6‐methyladenosine readers and neuroblastoma

Liping Chen; Jing He; Zhenjian Zhuo

doi:10.1002/ctd2.344

Clinical and Translational Discovery (Aug 2024)

The crosstalk between N6‐methyladenosine readers and neuroblastoma

Liping Chen,
Jing He,
Zhenjian Zhuo

Affiliations

Liping Chen: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China
Jing He: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China
Zhenjian Zhuo: Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China

DOI: https://doi.org/10.1002/ctd2.344
Journal volume & issue: Vol. 4, no. 4
pp. n/a – n/a

Abstract

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Abstract Background Neuroblastoma (NB) is a heterogeneous pediatric solid tumour strongly influenced by epigenetic modifications. Methods This review explores the role of N6‐methyladenosine (m6A) modifications and their readers in NB progression. Results Dysregulation of m6A readers, including YTHDF1/2, YTHDC1, IGF2BP1/2/3, HNRNPA2B1 and HNRNPC, has been associated with susceptibility and progression. Conclusion Understanding the crosstalk between m6A readers and NB could offer new insights into diagnosis, prognosis, and treatment strategies.

Published in Clinical and Translational Discovery

ISSN: 2768-0622 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://onlinelibrary.wiley.com/journal/27680622

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Abstract

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