Nature Communications (Apr 2016)
T-cell activation is an immune correlate of risk in BCG vaccinated infants
- Helen A. Fletcher,
- Margaret A. Snowden,
- Bernard Landry,
- Wasima Rida,
- Iman Satti,
- Stephanie A. Harris,
- Magali Matsumiya,
- Rachel Tanner,
- Matthew K. O’Shea,
- Veerabadran Dheenadhayalan,
- Leah Bogardus,
- Lisa Stockdale,
- Leanne Marsay,
- Agnieszka Chomka,
- Rachel Harrington-Kandt,
- Zita-Rose Manjaly-Thomas,
- Vivek Naranbhai,
- Elena Stylianou,
- Fatoumatta Darboe,
- Adam Penn-Nicholson,
- Elisa Nemes,
- Mark Hatherill,
- Gregory Hussey,
- Hassan Mahomed,
- Michele Tameris,
- J Bruce McClain,
- Thomas G. Evans,
- Willem A. Hanekom,
- Thomas J. Scriba,
- Helen McShane
Affiliations
- Helen A. Fletcher
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Margaret A. Snowden
- Aeras
- Bernard Landry
- Aeras
- Wasima Rida
- Biostatistics Consultant
- Iman Satti
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Stephanie A. Harris
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Magali Matsumiya
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Rachel Tanner
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Matthew K. O’Shea
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Veerabadran Dheenadhayalan
- Aeras
- Leah Bogardus
- Aeras
- Lisa Stockdale
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Leanne Marsay
- Department of Paediatrics, Oxford Vaccine Group, University of Oxford
- Agnieszka Chomka
- Nuffield Department of Orthopaedics, Kennedy Institute, Rheumatology and Musculoskeletal Sciences, University of Oxford
- Rachel Harrington-Kandt
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Zita-Rose Manjaly-Thomas
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Vivek Naranbhai
- Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford
- Elena Stylianou
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- Fatoumatta Darboe
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Adam Penn-Nicholson
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Elisa Nemes
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Mark Hatherill
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Gregory Hussey
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Hassan Mahomed
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Michele Tameris
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- J Bruce McClain
- Aeras
- Thomas G. Evans
- Aeras
- Willem A. Hanekom
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Thomas J. Scriba
- Department of Paediatrics and Child Health, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town
- Helen McShane
- Nuffield Department of Medicine, Jenner Institute, University of Oxford
- DOI
- https://doi.org/10.1038/ncomms11290
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
BCG vaccine confers only partial protection against tuberculosis. Here the authors show that the risk of tuberculosis infection and progression to disease in BCG-immunized children positively correlates with the frequency of activated HLA-DR+CD4+T cells.
