Significance of Single-Nucleotide Polymorphism rs4769628 in POMP Gene in the Development of Atopic Diseases in Children

Abstract

The objective of this study was to determine the correlation between single-nucleotide polymorphism rs4769628 in POMP gene and the development of allergic disease in children. Methods. Genotyping of single nucleotide polymorphism rs4769628 in POMP gene in children with manifestations of atopic march and apparently healthy children using real-time polymerase chain reaction. Results. 62.26 % of children with atopic diseases and 53.06 % healthy children had major allele rs4769628 in POMP gene. 33.67 and 37.76 % of children, respectively, had heterozygous AG variant. Minor GG genotype was not detected in children with atopic diseases, 9.18 % of healthy people are carriers of minor allele (р < 0.05). Conclusions. Minor G allele of rs4769628 in РОМР gene is associated with reduced risk of atopic diseases in children. Polymorphism rs4769628 in РОМР gene can be used as an important prognostic marker for the development of atopic diseases in children.

Keywords

• single-nucleotide polymorphism
• proteasomal proteolysis
• POMP
• atopic diseases
• children