Patterns of the Alterations of IL-1α Blood Level in Experimental Plague Intoxication

Abstract

Carried out was comparative evaluation of the alterations of IL-1α content in the blood serum and the level of the medium mass molecules under the conditions of treating with the Yersinia pestis lipopolysaccharide (LPS) in increasing doses (from LD25 up to 2LD50). Y. pestis LPS was shown to induce IL-1α generation by its cell-producers with subsequent realization of this cytokine local and systematic polymodal effects. While plague intoxication induced by Y. pestis LPS increasing doses administration progressed, IL-1α content remained stably high, even in endotoxin-caused shock.

Keywords

• <i>y. pestis</i>
• endotoxin
• interleukin-1α