Nature Communications (Jan 2021)
Accelerating functional gene discovery in osteoarthritis
- Natalie C. Butterfield,
- Katherine F. Curry,
- Julia Steinberg,
- Hannah Dewhurst,
- Davide Komla-Ebri,
- Naila S. Mannan,
- Anne-Tounsia Adoum,
- Victoria D. Leitch,
- John G. Logan,
- Julian A. Waung,
- Elena Ghirardello,
- Lorraine Southam,
- Scott E. Youlten,
- J. Mark Wilkinson,
- Elizabeth A. McAninch,
- Valerie E. Vancollie,
- Fiona Kussy,
- Jacqueline K. White,
- Christopher J. Lelliott,
- David J. Adams,
- Richard Jacques,
- Antonio C. Bianco,
- Alan Boyde,
- Eleftheria Zeggini,
- Peter I. Croucher,
- Graham R. Williams,
- J. H. Duncan Bassett
Affiliations
- Natalie C. Butterfield
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Katherine F. Curry
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Julia Steinberg
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Hannah Dewhurst
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Davide Komla-Ebri
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Naila S. Mannan
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Anne-Tounsia Adoum
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Victoria D. Leitch
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- John G. Logan
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Julian A. Waung
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Elena Ghirardello
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Lorraine Southam
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Scott E. Youlten
- The Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales Medicine
- J. Mark Wilkinson
- Department of Oncology and Metabolism, University of Sheffield
- Elizabeth A. McAninch
- Division of Endocrinology and Metabolism, Rush University Medical Center
- Valerie E. Vancollie
- Wellcome Trust Sanger Institute
- Fiona Kussy
- Wellcome Trust Sanger Institute
- Jacqueline K. White
- Wellcome Trust Sanger Institute
- Christopher J. Lelliott
- Wellcome Trust Sanger Institute
- David J. Adams
- Wellcome Trust Sanger Institute
- Richard Jacques
- School of Health and Related Research (ScHARR), University of Sheffield
- Antonio C. Bianco
- Section of Adult and Pediatric Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Chicago
- Alan Boyde
- Dental Physical Sciences, Queen Mary University of London, Mile End Road
- Eleftheria Zeggini
- Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
- Peter I. Croucher
- The Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales Medicine
- Graham R. Williams
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- J. H. Duncan Bassett
- Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-020-20761-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.
