Study of the correlation between vitamin D deficiency and chronic sinusitis in patients with bronchiectasis

Abstract

Objective To investigate the relationship between vitamin D deficiency and chronic sinusitis in patients with bronchiectasis. Methods A total of 119 patients with bronchiectasis were selected. Upon admission, serum 25-hydroxyvitamin D （25（OH）D）, serum total IgE and the proportion of eosinophil were detected, and sinus CT scan （Lund-Mackay score） was performed. According to whether the serum 25（OH）D level was less than 20 ng/mL, all patients were divided into the vitamin D deficiency group （< 20 ng/mL） and normal group （≥20 ng/mL）. The incidence of chronic sinusitis in patients with bronchiectasis was statistically compared between two groups. Lund-Mackay score in bronchiectasis patients complicated with sinusitis was compared between two groups. Moreover, the correlation between serum 25（OH）D level and Lund-Mackay score in bronchiectasis patients complicated with sinusitis was analyzed. Results Among 119 patients with bronchiectasis, 69 cases developed vitamin D deficiency and 50 had normal vitamin D levels; 71 of them were complicated with sinusitis, accounting for 59.7%, and 48 patients had no sinus abnormality. Compared with the normal group, the incidence of chronic sinusitis were significantly higher in the vitamin D deficiency group （both P < 0.05）. Among 71 bronchiectasis patients complicated with chronic sinusitis, Lund-Mackay score in the vitamin D deficiency group was considerably higher than that in the normal group （P < 0.05）. In bronchiectasis patients complicated with chronic sinusitis, serum 25（OH）D level was negatively correlated with Lund-Mackay score （P < 0.05）. Conclusion In bronchiectasis patients, vitamin D deficiency is correlated with the incidence and progression of chronic sinusitis.

Keywords

• |vitamin d|bronchiectasis|sinusitis|lund-mackay score|combined airway disease