The RAD51 recombinase protects mitotic chromatin in human cells

Isabel E. Wassing; Emily Graham; Xanita Saayman; Lucia Rampazzo; Christine Ralf; Andrew Bassett; Fumiko Esashi

doi:10.1038/s41467-021-25643-y

Nature Communications (Sep 2021)

The RAD51 recombinase protects mitotic chromatin in human cells

Isabel E. Wassing,
Emily Graham,
Xanita Saayman,
Lucia Rampazzo,
Christine Ralf,
Andrew Bassett,
Fumiko Esashi

Affiliations

Isabel E. Wassing: Sir William Dunn School of Pathology, University of Oxford
Emily Graham: Sir William Dunn School of Pathology, University of Oxford
Xanita Saayman: Sir William Dunn School of Pathology, University of Oxford
Lucia Rampazzo: Sir William Dunn School of Pathology, University of Oxford
Christine Ralf: Sir William Dunn School of Pathology, University of Oxford
Andrew Bassett: Wellcome Sanger Institute
Fumiko Esashi: Sir William Dunn School of Pathology, University of Oxford

DOI: https://doi.org/10.1038/s41467-021-25643-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

Read online

RAD51 is a well known player of DNA repair and homologous recombination. Here the authors reveal a function for RAD51 in protecting under-replicated DNA in mitotic human cells, promoting mitotic DNA synthesis (MiDAS) and successful chromosome segregation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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