Communications Biology (Jan 2022)
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease
- Florian Uellendahl-Werth,
- Carlo Maj,
- Oleg Borisov,
- Simonas Juzenas,
- Eike Matthias Wacker,
- Isabella Friis Jørgensen,
- Tim Alexander Steiert,
- Saptarshi Bej,
- Peter Krawitz,
- Per Hoffmann,
- Christoph Schramm,
- Olaf Wolkenhauer,
- Karina Banasik,
- Søren Brunak,
- Stefan Schreiber,
- Tom Hemming Karlsen,
- Franziska Degenhardt,
- Markus Nöthen,
- Andre Franke,
- Trine Folseraas,
- David Ellinghaus
Affiliations
- Florian Uellendahl-Werth
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Carlo Maj
- Institute for Genomic Statistics and Bioinformatics, University of Bonn
- Oleg Borisov
- Institute for Genomic Statistics and Bioinformatics, University of Bonn
- Simonas Juzenas
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Eike Matthias Wacker
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Isabella Friis Jørgensen
- Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen
- Tim Alexander Steiert
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Saptarshi Bej
- Department of Systems Biology & Bioinformatics, University of Rostock
- Peter Krawitz
- Institute for Genomic Statistics and Bioinformatics, University of Bonn
- Per Hoffmann
- Department of Genomics, Life & Brain Center, University of Bonn
- Christoph Schramm
- First Department of Internal Medicine, University Medical Center Hamburg-Eppendorf
- Olaf Wolkenhauer
- Department of Systems Biology & Bioinformatics, University of Rostock
- Karina Banasik
- Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen
- Søren Brunak
- Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen
- Stefan Schreiber
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Tom Hemming Karlsen
- Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo
- Franziska Degenhardt
- Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen
- Markus Nöthen
- Department of Genomics, Life & Brain Center, University of Bonn
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Trine Folseraas
- Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo
- David Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- DOI
- https://doi.org/10.1038/s42003-022-03031-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Florian Uellendahl-Werth et al. conduct cross-tissue transcriptome-wide association studies to explore genetic mechanisms shared across immune-related and psychiatric traits. Their results identify several genes (including PPP3CA) that could mediate the interplay between psychiatric and inflammatory disease.
