Research Progress on Low Specific Activity 99Mo-99mTc Generators

Abstract

The radioisotope 99mTc is widely used in the clinical diagnostic field of nuclear medicine，which is mainly obtained by β-decay of the parent nuclide 99Mo in 99Mo-99mTc generator. Due to the shutdown of multiple reactors producing 99Mo，the stable supply of fission 99Mo is threatened. In addition，the production of fission 99Mo may lead to nuclear proliferation. As a result，the raw materials for the fission-99Mo-99mTc generators decreased. Therefore，reactor irradiation and accelerator-based 99Mo production technology have attracted the attention of various countries. New 99Mo-99mTc generators are also constantly being developed. This paper briefly discusses the current production status of low specific activity 99Mo in China and the separation methods of low specific activity 99Mo-99mTc. Furthermore，the 99Mo-99mTc generator is also discussed，which is expected to provide some reference for the development of new 99Mo-99mTc generators in the future.

Keywords

• low specific activity
• production of 99mo
• 99mo-99mtc generator