Nature Communications (Mar 2017)

Catalytic asymmetric radical aminoperfluoroalkylation and aminodifluoromethylation of alkenes to versatile enantioenriched-fluoroalkyl amines

  • Jin-Shun Lin,
  • Fu-Li Wang,
  • Xiao-Yang Dong,
  • Wei-Wei He,
  • Yue Yuan,
  • Su Chen,
  • Xin-Yuan Liu

DOI
https://doi.org/10.1038/ncomms14841
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Methods for the asymmetric introduction of organofluorine groups are often limited by the lack of variability in the starting materials. Here the authors report an asymmetric radical process for the introduction of fluoroalkyl groups using readily available fluoroalkylated sulfonyl chlorides.