NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

Suraj Peri; Evgeny Izumchenko; Adrian D. Schubert; Michael J. Slifker; Karen Ruth; Ilya G. Serebriiskii; Theresa Guo; Barbara A. Burtness; Ranee Mehra; Eric A. Ross; David Sidransky; Erica A. Golemis

doi:10.1038/s41467-017-01877-7

Nature Communications (Nov 2017)

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

Suraj Peri,
Evgeny Izumchenko,
Adrian D. Schubert,
Michael J. Slifker,
Karen Ruth,
Ilya G. Serebriiskii,
Theresa Guo,
Barbara A. Burtness,
Ranee Mehra,
Eric A. Ross,
David Sidransky,
Erica A. Golemis

Affiliations

Suraj Peri: Biostatistics and Bioinformatics Division, Fox Chase Cancer Center
Evgeny Izumchenko: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine
Adrian D. Schubert: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine
Michael J. Slifker: Biostatistics and Bioinformatics Division, Fox Chase Cancer Center
Karen Ruth: Biostatistics and Bioinformatics Division, Fox Chase Cancer Center
Ilya G. Serebriiskii: Molecular Therapeutics Program, Fox Chase Cancer Center
Theresa Guo: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine
Barbara A. Burtness: Department of Internal Medicine and Developmental Therapeutics Program, Yale Cancer Center, Yale School of Medicine, Yale University
Ranee Mehra: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine
Eric A. Ross: Biostatistics and Bioinformatics Division, Fox Chase Cancer Center
David Sidransky: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine
Erica A. Golemis: Molecular Therapeutics Program, Fox Chase Cancer Center

DOI: https://doi.org/10.1038/s41467-017-01877-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with laryngeal, but not other head and neck cancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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