Nature Communications (Jun 2021)
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
- Celia de la Calle Arregui,
- Ana Belén Plata-Gómez,
- Nerea Deleyto-Seldas,
- Fernando García,
- Ana Ortega-Molina,
- Julio Abril-Garrido,
- Elena Rodriguez,
- Ivan Nemazanyy,
- Laura Tribouillard,
- Alba de Martino,
- Eduardo Caleiras,
- Ramón Campos-Olivas,
- Francisca Mulero,
- Mathieu Laplante,
- Javier Muñoz,
- Mario Pende,
- Guadalupe Sabio,
- David M. Sabatini,
- Alejo Efeyan
Affiliations
- Celia de la Calle Arregui
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- Ana Belén Plata-Gómez
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- Nerea Deleyto-Seldas
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- Fernando García
- Proteomics Unit, Spanish National Cancer Research Centre (CNIO)
- Ana Ortega-Molina
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- Julio Abril-Garrido
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- Elena Rodriguez
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- Ivan Nemazanyy
- Platform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633
- Laura Tribouillard
- Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval
- Alba de Martino
- Histopathology Unit. Spanish National Cancer Research Centre (CNIO)
- Eduardo Caleiras
- Histopathology Unit. Spanish National Cancer Research Centre (CNIO)
- Ramón Campos-Olivas
- Spectroscopy and NMR Unit, Spanish National Cancer Research Centre (CNIO)
- Francisca Mulero
- Molecular Imaging Unit, Spanish National Cancer Research Centre (CNIO)
- Mathieu Laplante
- Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval
- Javier Muñoz
- Proteomics Unit, Spanish National Cancer Research Centre (CNIO)
- Mario Pende
- Institut Necker Enfants Malades, INSERM U1151, Université de Paris
- Guadalupe Sabio
- Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
- David M. Sabatini
- Whitehead Institute for Biomedical Research, Nine Cambridge Center
- Alejo Efeyan
- Metabolism and Cell Signaling Laboratory, Spanish National Cancer Research Centre (CNIO)
- DOI
- https://doi.org/10.1038/s41467-021-23857-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show that constitutive nutrient signaling regulates the response to feeding-fasting cycles and does not drive liver cancer.
