OCD in animal models using quinpirole as dopaminergic inductor of perseverative behaviour

C. Campos-García Rojas; F. Jiménez-Ponce; A. Flores-Vargas; A.P. García

doi:10.1016/j.hgmx.2015.09.002

Revista Médica del Hospital General de México (Oct 2015)

OCD in animal models using quinpirole as dopaminergic inductor of perseverative behaviour

C. Campos-García Rojas,
F. Jiménez-Ponce,
A. Flores-Vargas,
A.P. García

Affiliations

C. Campos-García Rojas: Servicio de Cirugía Experimental del Hospital General de México “Dr. Eduardo Liceaga”,
F. Jiménez-Ponce: Neurocirugía Clínica, Hospital Ángeles del Pedregal,
A. Flores-Vargas: Servicio Social en Investigación de la Universidad Autónoma del Estado de México,
A.P. García: Servicio de Cirugía Experimental del Hospital General de México “Dr. Eduardo Liceaga”,

DOI: https://doi.org/10.1016/j.hgmx.2015.09.002
Journal volume & issue: Vol. 78, no. 4
pp. 169 – 176

Abstract

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In the reviewed articles, quinpirole is used as a dopamine D2 and D3 receptor agonist to induce persistent behaviour in animal models. Dopamine has been related to perseverative behaviour. The perseverative behaviour was observed in an open field with objects of different shapes and sizes. The main structures studied with this methodology are the orbitofrontal cortex, striatum, thalamus, basolateral amygdala and nucleus accumbens. The animal models studied comply with the face, predictive and construct validity.

Published in Revista Médica del Hospital General de México

ISSN: 0185-1063 (Print)
Publisher: Permanyer
Country of publisher: Mexico
LCC subjects: Medicine: Medicine (General)
Website: http://www.hospitalgeneral.mx/

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