Nature Communications (Dec 2022)
The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
- Louisa L. Y. Chan,
- Danielle E. Anderson,
- Hong Sheng Cheng,
- Fransiskus Xaverius Ivan,
- Si Chen,
- Adrian E. Z. Kang,
- Randy Foo,
- Akshamal M. Gamage,
- Pei Yee Tiew,
- Mariko Siyue Koh,
- Ken Cheah Hooi Lee,
- Kristy Nichol,
- Prabuddha S. Pathinayake,
- Yik Lung Chan,
- Tsin Wen Yeo,
- Brian G. Oliver,
- Peter A. B. Wark,
- Linbo Liu,
- Nguan Soon Tan,
- Lin-Fa Wang,
- Sanjay H. Chotirmall
Affiliations
- Louisa L. Y. Chan
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Danielle E. Anderson
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Hong Sheng Cheng
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Fransiskus Xaverius Ivan
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Si Chen
- School of Electrical and Electronic Engineering, Nanyang Technological University
- Adrian E. Z. Kang
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Randy Foo
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Akshamal M. Gamage
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Pei Yee Tiew
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Mariko Siyue Koh
- Department of Respiratory and Critical Care Medicine, Singapore General Hospital
- Ken Cheah Hooi Lee
- Department of Respiratory and Critical Care Medicine, Singapore General Hospital
- Kristy Nichol
- Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle
- Prabuddha S. Pathinayake
- Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle
- Yik Lung Chan
- School of Life Sciences, Faculty of Science, University of Technology Sydney
- Tsin Wen Yeo
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Brian G. Oliver
- School of Life Sciences, Faculty of Science, University of Technology Sydney
- Peter A. B. Wark
- Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle
- Linbo Liu
- School of Electrical and Electronic Engineering, Nanyang Technological University
- Nguan Soon Tan
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Lin-Fa Wang
- Programme in Emerging Infectious Diseases, Duke-NUS Medical School
- Sanjay H. Chotirmall
- Lee Kong Chian School of Medicine, Nanyang Technological University
- DOI
- https://doi.org/10.1038/s41467-022-35253-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.
