Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Corey Rogers; Teresa Fernandes-Alnemri; Lindsey Mayes; Diana Alnemri; Gino Cingolani; Emad S. Alnemri

doi:10.1038/ncomms14128

Nature Communications (Jan 2017)

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Corey Rogers,
Teresa Fernandes-Alnemri,
Lindsey Mayes,
Diana Alnemri,
Gino Cingolani,
Emad S. Alnemri

Affiliations

Corey Rogers: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University
Teresa Fernandes-Alnemri: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University
Lindsey Mayes: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University
Diana Alnemri: Schreyer Honors College, Pennsylvania State University
Gino Cingolani: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University
Emad S. Alnemri: Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University

DOI: https://doi.org/10.1038/ncomms14128
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

DFNA5 is related to the caspase-dependent pyroptosis inducer gasdermin D. Here the authors find that DFNA5 is cleaved by caspase 3 and show this cleavage skews cells away from apoptosis into secondary necrosis, a form of cell death characterized by membrane ballooning similar to pyroptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal