A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

Yueyuan Zheng; Guowei Huang; Tiago C. Silva; Qian Yang; Yan-Yi Jiang; H. Phillip Koeffler; De-Chen Lin; Benjamin P. Berman

doi:10.1038/s41467-021-22720-0

Nature Communications (Apr 2021)

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

Yueyuan Zheng,
Guowei Huang,
Tiago C. Silva,
Qian Yang,
Yan-Yi Jiang,
H. Phillip Koeffler,
De-Chen Lin,
Benjamin P. Berman

Affiliations

Yueyuan Zheng: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Guowei Huang: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Tiago C. Silva: Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center
Qian Yang: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Yan-Yi Jiang: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
H. Phillip Koeffler: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
De-Chen Lin: Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Benjamin P. Berman: Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School

DOI: https://doi.org/10.1038/s41467-021-22720-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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