Research progress of automated micronucleus analysis technology for cytokinesis arrest

Abstract

In the field of radiation biological dose estimation, cytokinesis-blocked micronucleus analysis (CBMN method) is the best internationally recognized estimation approach, excluding chromosomal aberrations. To overcome the limitations of the artificial CBMN method, namely the large amount of time and labor required for its execution, automated methods are being widely explored to detect binuclear cell micronuclei. This study involves an analysis of the relevant literature on an international level and an inspection and summary of the research on CBMN automated analysis so as to fully describe the current research progress and characteristics thereof. On this basis, future development trends of CBMN automated analysis can be predicted to provide useful references for researchers in related fields.

Keywords

• cytokinesis block micronucleus
• automatic image acquisition
• automatic analysis algorithm