Frontiers in Oncology (Nov 2021)

An Assessment of Ovarian Cancer Histotypes Across the African Diaspora

  • Sophia H. L. George,
  • Sophia H. L. George,
  • Sophia H. L. George,
  • Ayodele Omotoso,
  • Ayodele Omotoso,
  • Andre Pinto,
  • Andre Pinto,
  • Aisha Mustapha,
  • Aisha Mustapha,
  • Alex P. Sanchez-Covarrubias,
  • Usman Aliyu Umar,
  • Usman Aliyu Umar,
  • Ali Bala Umar,
  • Ali Bala Umar,
  • Timothy Abiola Oluwasola,
  • Timothy Abiola Oluwasola,
  • Clement Abu Okolo,
  • Clement Abu Okolo,
  • Umeh Uchenna Anthony,
  • Umeh Uchenna Anthony,
  • Francis Ikechukwu Ukekwe,
  • Francis Ikechukwu Ukekwe,
  • Maisaratu A. Bakari,
  • Maisaratu A. Bakari,
  • Aminu M. C. Dahiru,
  • Aminu M. C. Dahiru,
  • Habiba Ibrahim Abdullahi,
  • Habiba Ibrahim Abdullahi,
  • Bawa Ahmed Abimiku,
  • Bawa Ahmed Abimiku,
  • Aisha Abdurrahman,
  • Aisha Abdurrahman,
  • Asmau Usman,
  • Asmau Usman,
  • Saad Aliyu Ahmed,
  • Saad Aliyu Ahmed,
  • Hadiza Abdullahi Usman,
  • Hadiza Abdullahi Usman,
  • Abba Kabir,
  • Abba Kabir,
  • George Uchenna Eleje,
  • George Uchenna Eleje,
  • Michael Emeka Chiemeka,
  • Michael Emeka Chiemeka,
  • Emily Nzeribe,
  • Emily Nzeribe,
  • Ikechukwu Nweke,
  • Ikechukwu Nweke,
  • SaiduAbubakar Kadas,
  • SaiduAbubakar Kadas,
  • Dauda E. Suleiman,
  • Dauda E. Suleiman,
  • Etim Ekanem,
  • Etim Ekanem,
  • Umemmuo Maureen Uche,
  • Umemmuo Maureen Uche,
  • Jibrin Paul,
  • Jibrin Paul,
  • Uzoma Maryrose Agwu,
  • Uzoma Maryrose Agwu,
  • Felix O. Edegbe,
  • Felix O. Edegbe,
  • Rose I. Anorlu,
  • Rose I. Anorlu,
  • Adekunbiola Banjo,
  • Adekunbiola Banjo,
  • Kayode Olusegun Ajenifuja,
  • Kayode Olusegun Ajenifuja,
  • Adegboyega Adisa Fawole,
  • Adegboyega Adisa Fawole,
  • Ibrahim O. O. Kazeem,
  • Ibrahim O. O. Kazeem,
  • Francis Magaji,
  • Francis Magaji,
  • Olugbenga Silas,
  • Olugbenga Silas,
  • Boma Precious Athanasius,
  • Boma Precious Athanasius,
  • Nyengidiki Kennedy Tamunomie,
  • Nyengidiki Kennedy Tamunomie,
  • Emem Bassey,
  • Emem Bassey,
  • Kunle Abudu,
  • Kunle Abudu,
  • Ibrahim G. Ango,
  • Ibrahim G. Ango,
  • Kabiru Abdullahi,
  • Kabiru Abdullahi,
  • Ishak Lawal,
  • Ishak Lawal,
  • Suleiman Aliyu Kabir,
  • Suleiman Aliyu Kabir,
  • Victor Ekanem,
  • Victor Ekanem,
  • Michael Ezeanochie,
  • Michael Ezeanochie,
  • Usman Rahman Yahaya,
  • Usman Rahman Yahaya,
  • Melissa Nicole Castillo,
  • Vishal Bahall,
  • Vikash Chatrani,
  • Ian Brambury,
  • Ian Brambury,
  • Saida Bowe,
  • Saida Bowe,
  • Darron Halliday,
  • Darron Halliday,
  • George Bruney,
  • Raleigh Butler,
  • Raleigh Butler,
  • Camille Ragin,
  • Camille Ragin,
  • Folakemi Odedina,
  • Folakemi Odedina,
  • Srikar Chamala,
  • Matthew Schlumbrecht,
  • Matthew Schlumbrecht,
  • Matthew Schlumbrecht,
  • Bala Audu,
  • Bala Audu,
  • Bala Audu

DOI
https://doi.org/10.3389/fonc.2021.732443
Journal volume & issue
Vol. 11

Abstract

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ObjectiveOvarian cancer in Black women is common in many West African countries but is relatively rare in North America. Black women have worse survival outcomes when compared to White women. Ovarian cancer histotype, diagnosis, and age at presentation are known prognostic factors for outcome. We sought to conduct a preliminary comparative assessment of these factors across the African diaspora.MethodsPatients diagnosed with ovarian cancer (all histologies) between June 2016-December 2019 in Departments of Pathology at 25 participating sites in Nigeria were identified. Comparative population-based data, inclusive of Caribbean-born Blacks (CBB) and US-born Blacks (USB), were additionally captured from the International Agency for Research on Cancer and Florida Cancer Data Systems. Histology, country of birth, and age at diagnosis data were collected and evaluated across the three subgroups: USB, CBB and Nigerians. Statistical analyses were done using chi-square and student’s t-test with significance set at p<0.05.ResultsNigerians had the highest proportion of germ cell tumor (GCT, 11.5%) and sex-cord stromal (SCST, 16.2%) ovarian cancers relative to CBB and USB (p=0.001). CBB (79.4%) and USB (77.3%) women were diagnosed with a larger proportion of serous ovarian cancer than Nigerians (60.4%) (p<0.0001). Nigerians were diagnosed with epithelial ovarian cancers at the youngest age (51.7± 12.8 years) relative to USB (58.9 ± 15.0) and CBB (59.0± 13.0,p<0.001). Black women [CBB (25.2 ± 15.0), Nigerians (29.5 ± 15.1), and USB (33.9 ± 17.9)] were diagnosed with GCT younger than White women (35.4 ± 20.5, p=0.011). Black women [Nigerians (47.5 ± 15.9), USB (50.9 ± 18.3) and CBB (50.9 ± 18.3)] were also diagnosed with SCST younger than White women (55.6 ± 16.5, p<0.01).ConclusionThere is significant variation in age of diagnosis and distribution of ovarian cancer histotype/diagnosis across the African diaspora. The etiology of these findings requires further investigation.

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