Nature Communications (Jul 2020)
Proteome activity landscapes of tumor cell lines determine drug responses
- Martin Frejno,
- Chen Meng,
- Benjamin Ruprecht,
- Thomas Oellerich,
- Sebastian Scheich,
- Karin Kleigrewe,
- Enken Drecoll,
- Patroklos Samaras,
- Alexander Hogrebe,
- Dominic Helm,
- Julia Mergner,
- Jana Zecha,
- Stephanie Heinzlmeir,
- Mathias Wilhelm,
- Julia Dorn,
- Hans-Michael Kvasnicka,
- Hubert Serve,
- Wilko Weichert,
- Bernhard Kuster
Affiliations
- Martin Frejno
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Chen Meng
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Benjamin Ruprecht
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Thomas Oellerich
- Department of Medicine, Hematology/Oncology, Goethe-University
- Sebastian Scheich
- Department of Medicine, Hematology/Oncology, Goethe-University
- Karin Kleigrewe
- Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich
- Enken Drecoll
- Institute of Pathology, Technical University of Munich
- Patroklos Samaras
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Alexander Hogrebe
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Dominic Helm
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Julia Mergner
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Jana Zecha
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Stephanie Heinzlmeir
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Mathias Wilhelm
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- Julia Dorn
- Klinikum rechts der Isar, Technical University of Munich
- Hans-Michael Kvasnicka
- Institute of Pathology, Goethe University
- Hubert Serve
- Department of Medicine, Hematology/Oncology, Goethe-University
- Wilko Weichert
- German Cancer Consortium (DKTK)
- Bernhard Kuster
- Chair of Proteomics and Bioanalytics, Technical University of Munich
- DOI
- https://doi.org/10.1038/s41467-020-17336-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Proteome activity has a major role in cancer progression and response to drugs. Here, the authors use comprehensive proteomic and phosphoproteomic data, in conjunction with drug-sensitivity screens, to generate a community resource consisting of landscapes of pathway and kinase activity across different cell lines
