Frontiers in Neuroscience (Feb 2023)

Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer’s disease in individuals with mild cognitive impairment: The NORFACE cohort

  • Marta Marquié,
  • Marta Marquié,
  • Ainhoa García-Sánchez,
  • Emilio Alarcón-Martín,
  • Joan Martínez,
  • Miguel Castilla-Martí,
  • Miguel Castilla-Martí,
  • Luis Castilla-Martí,
  • Luis Castilla-Martí,
  • Adelina Orellana,
  • Adelina Orellana,
  • Laura Montrreal,
  • Itziar de Rojas,
  • Itziar de Rojas,
  • Pablo García-González,
  • Pablo García-González,
  • Raquel Puerta,
  • Clàudia Olivé,
  • Amanda Cano,
  • Amanda Cano,
  • Isabel Hernández,
  • Maitée Rosende-Roca,
  • Liliana Vargas,
  • Juan Pablo Tartari,
  • Ester Esteban-De Antonio,
  • Urszula Bojaryn,
  • Mario Ricciardi,
  • Diana M. Ariton,
  • Vanesa Pytel,
  • Montserrat Alegret,
  • Montserrat Alegret,
  • Gemma Ortega,
  • Gemma Ortega,
  • Ana Espinosa,
  • Ana Espinosa,
  • Alba Pérez-Cordón,
  • Ángela Sanabria,
  • Ángela Sanabria,
  • Nathalia Muñoz,
  • Núria Lleonart,
  • Núria Aguilera,
  • Lluís Tárraga,
  • Lluís Tárraga,
  • Sergi Valero,
  • Sergi Valero,
  • Agustín Ruiz,
  • Agustín Ruiz,
  • Mercè Boada,
  • Mercè Boada

DOI
https://doi.org/10.3389/fnins.2023.1076177
Journal volume & issue
Vol. 17

Abstract

Read online

BackgroundOptical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer’s disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. We aimed to investigate the association of macular vessel density (VD) in the superficial plexus quantified by OCT-A with the AT(N) classification based on cerebrospinal fluid (CSF) Aβ1-42, p181-tau and t-tau measurements in individuals with mild cognitive impairment (MCI).Materials and methodsClinical, demographic, ophthalmological, OCT-A and CSF core biomarkers for AD data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences in macular VD in four quadrants (superior, nasal, inferior, and temporal) among three AT(N) groups [Normal, Alzheimer and Suspected non-Alzheimer pathology (SNAP)] were assessed in a multivariate regression model, adjusted for age, APOE ε4 status, hypertension, diabetes mellitus, dyslipidemia, heart disease, chronic obstructive pulmonary disease and smoking habit, using the Normal AT(N) group as the reference category.ResultsThe study cohort comprised 144 MCI participants: 66 Normal AT(N), 45 Alzheimer AT(N) and 33 SNAP AT(N). Regression analysis showed no significant association of the AT(N) groups with any of the regional macular VD measures (all, p > 0.16). The interaction between sex and AT(N) groups had no effect on differentiating VD. Lastly, CSF Aβ1-42, p181-tau and t-tau measures were not correlated to VD (all r < 0.13; p > 0.13).DiscussionOur study showed that macular VD measures were not associated with the AT(N) classification based on CSF biomarkers in patients with MCI, and did not differ between AD and other underlying causes of cognitive decline in our cohort.

Keywords