Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin

Abstract

Background: Preeclampsia (PE) is a disorder of pregnancy associated with vitamin D (VD) deficiency. Chemerin is an adipokine significantly increased in preeclampsia and is regulated by VD. Objectives: To determine whether VD supplementation would protect against development of PE through Chemerin reduction Methods: PE was induced in albino rats by injection of 12.5 mg of deoxycorticosterone (DOCA). Rats were randomly divided into normal pregnant, PE group, VD supplemented PE group. Results: VD supplementation decreased systolic blood pressure, proteinuria and decreased serum Chemerin level. Conclusion: VD treatment reduced Chemerin level, and blood pressure in DOCA rat model of PE.

Keywords

• preeclampsia
• vitamin d
• chemerin
• placenta
• systolic blood pressure