NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4

Abstract

The inflammatory response of macrophages is responsible for sepsis. Long noncoding RNA nuclear enriched abundant transcript 1 (NEAT1) has been reported to be involved in sepsis development. However, its underlying mechanism remains largely unclear. This study aims to investigate the effect of NEAT1 on inflammatory response of macrophages and explore the regulatory network of NEAT1/microRNA-17-5p (miR-17-5p)/Toll-like receptor 4 (TLR4).

Keywords

• sepsis
• inflammatory response
• neat1
• mir-17-5p
• tlr4