Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Kevin H. Toomer; Jen Bon Lui; Norman H. Altman; Yuguang Ban; Xi Chen; Thomas R. Malek

doi:10.1038/s41467-019-08960-1

Nature Communications (Mar 2019)

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

Kevin H. Toomer,
Jen Bon Lui,
Norman H. Altman,
Yuguang Ban,
Xi Chen,
Thomas R. Malek

Affiliations

Kevin H. Toomer: Department of Microbiology and Immunology, Miller School of Medicine, University of Miami
Jen Bon Lui: Department of Microbiology and Immunology, Miller School of Medicine, University of Miami
Norman H. Altman: Department of Pathology, Miller School of Medicine, University of Miami
Yuguang Ban: Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Xi Chen: Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
Thomas R. Malek: Department of Microbiology and Immunology, Miller School of Medicine, University of Miami

DOI: https://doi.org/10.1038/s41467-019-08960-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Interleukin-2 (IL-2) signaling is required for regulatory T (Treg) cell differentiation in the thymus, but its function in peripheral Tregs is still unclear. Here the authors show, using inducible deletion of IL-2 receptor subunit CD25, that IL-2 signaling is essential for maintaining peripheral Treg homeostasis, but dispensable for lineage stability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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