Nature Communications (Dec 2022)
Regulation of bone homeostasis by MERTK and TYRO3
- Janik Engelmann,
- Jennifer Zarrer,
- Victoria Gensch,
- Kristoffer Riecken,
- Nikolaus Berenbrok,
- The Vinh Luu,
- Antonia Beitzen-Heineke,
- Maria Elena Vargas-Delgado,
- Klaus Pantel,
- Carsten Bokemeyer,
- Somasekhar Bhamidipati,
- Ihab S. Darwish,
- Esteban Masuda,
- Tal Burstyn-Cohen,
- Emily J. Alberto,
- Sourav Ghosh,
- Carla Rothlin,
- Eric Hesse,
- Hanna Taipaleenmäki,
- Isabel Ben-Batalla,
- Sonja Loges
Affiliations
- Janik Engelmann
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Jennifer Zarrer
- Molecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf
- Victoria Gensch
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Kristoffer Riecken
- Department of Stem Cell Transplantation, Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf
- Nikolaus Berenbrok
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- The Vinh Luu
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Antonia Beitzen-Heineke
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Maria Elena Vargas-Delgado
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Klaus Pantel
- Department of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf
- Carsten Bokemeyer
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Somasekhar Bhamidipati
- Rigel Pharmaceuticals, Inc.
- Ihab S. Darwish
- Rigel Pharmaceuticals, Inc.
- Esteban Masuda
- Rigel Pharmaceuticals, Inc.
- Tal Burstyn-Cohen
- Faculty of Dental Medicine, Institute for Dental Sciences, The Hebrew University of Jerusalem
- Emily J. Alberto
- Department of Immunobiology, Yale University School of Medicine
- Sourav Ghosh
- Department of Pharmacology, Yale University School of Medicine
- Carla Rothlin
- Department of Immunobiology, Yale University School of Medicine
- Eric Hesse
- Institute of Musculoskeletal Medicine, University Hospital, LMU Munich
- Hanna Taipaleenmäki
- Molecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf
- Isabel Ben-Batalla
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Sonja Loges
- Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-022-33938-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated osteolytic bone disease
