Nature Communications (Mar 2018)
The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
- Stefanie Wojciech,
- Raise Ahmad,
- Zakia Belaid-Choucair,
- Anne-Sophie Journé,
- Sarah Gallet,
- Julie Dam,
- Avais Daulat,
- Delphine Ndiaye-Lobry,
- Olivier Lahuna,
- Angeliki Karamitri,
- Jean-Luc Guillaume,
- Marcio Do Cruzeiro,
- François Guillonneau,
- Anastasia Saade,
- Nathalie Clément,
- Thomas Courivaud,
- Nawel Kaabi,
- Kenjiro Tadagaki,
- Philippe Delagrange,
- Vincent Prévot,
- Olivier Hermine,
- Céline Prunier,
- Ralf Jockers
Affiliations
- Stefanie Wojciech
- Inserm, U1016, Institut Cochin
- Raise Ahmad
- Inserm, U1016, Institut Cochin
- Zakia Belaid-Choucair
- Université Paris Descartes, Université Sorbonne Paris Cité
- Anne-Sophie Journé
- Inserm, U1016, Institut Cochin
- Sarah Gallet
- Jean-Pierre Aubert Research Center
- Julie Dam
- Inserm, U1016, Institut Cochin
- Avais Daulat
- Inserm, U1016, Institut Cochin
- Delphine Ndiaye-Lobry
- Inserm, U1016, Institut Cochin
- Olivier Lahuna
- Inserm, U1016, Institut Cochin
- Angeliki Karamitri
- Inserm, U1016, Institut Cochin
- Jean-Luc Guillaume
- Inserm, U1016, Institut Cochin
- Marcio Do Cruzeiro
- Inserm, U1016, Institut Cochin
- François Guillonneau
- Inserm, U1016, Institut Cochin
- Anastasia Saade
- Inserm, U1016, Institut Cochin
- Nathalie Clément
- Inserm, U1016, Institut Cochin
- Thomas Courivaud
- Sorbonne Université, UPMC Univ Paris 06, INSERM, Centre de Recherche Saint-Antoine (CRSA)
- Nawel Kaabi
- Sorbonne Université, UPMC Univ Paris 06, INSERM, Centre de Recherche Saint-Antoine (CRSA)
- Kenjiro Tadagaki
- Inserm, U1016, Institut Cochin
- Philippe Delagrange
- Institut de Recherches SERVIER
- Vincent Prévot
- Jean-Pierre Aubert Research Center
- Olivier Hermine
- Université Paris Descartes, Université Sorbonne Paris Cité
- Céline Prunier
- Sorbonne Université, UPMC Univ Paris 06, INSERM, Centre de Recherche Saint-Antoine (CRSA)
- Ralf Jockers
- Inserm, U1016, Institut Cochin
- DOI
- https://doi.org/10.1038/s41467-018-03609-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Transforming growth factor-β (TGFβ) regulates many cellular processes. Here the authors show that the orphan G-protein coupled receptor GPR50 can activate the TGFβ receptor I, in the absence of TGFβ, by stabilizing its active conformation and show antitumor activity in a mouse model of breast cancer.
