Nature Communications (Apr 2022)
Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
- Qi Zhao,
- Feng Wang,
- Yan-Xing Chen,
- Shifu Chen,
- Yi-Chen Yao,
- Zhao-Lei Zeng,
- Teng-Jia Jiang,
- Ying-Nan Wang,
- Chen-Yi Wu,
- Ying Jing,
- You-Sheng Huang,
- Jing Zhang,
- Zi-Xian Wang,
- Ming-Ming He,
- Heng-Ying Pu,
- Zong-Jiong Mai,
- Qi-Nian Wu,
- Renwen Long,
- Xiaoni Zhang,
- Tanxiao Huang,
- Mingyan Xu,
- Miao-Zheng Qiu,
- Hui-Yan Luo,
- Yu-Hong Li,
- Dong-Shen Zhang,
- Wei-Hua Jia,
- Gong Chen,
- Pei-Rong Ding,
- Li-Ren Li,
- Zheng-Hai Lu,
- Zhi-Zhong Pan,
- Rui-Hua Xu
Affiliations
- Qi Zhao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Feng Wang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Yan-Xing Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Shifu Chen
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Yi-Chen Yao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Zhao-Lei Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Teng-Jia Jiang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Ying-Nan Wang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Chen-Yi Wu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Ying Jing
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- You-Sheng Huang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Jing Zhang
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Zi-Xian Wang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Ming-Ming He
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Heng-Ying Pu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Zong-Jiong Mai
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Qi-Nian Wu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Renwen Long
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Xiaoni Zhang
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Tanxiao Huang
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Mingyan Xu
- HaploX Biotechnology, Co., Ltd., 8th floor, Auto Electric Power Building
- Miao-Zheng Qiu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Hui-Yan Luo
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Yu-Hong Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Dong-Shen Zhang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Wei-Hua Jia
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Gong Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Pei-Rong Ding
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Li-Ren Li
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Zheng-Hai Lu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Zhi-Zhong Pan
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- Rui-Hua Xu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-022-30062-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The ChangKang (Heathy Bowel) project was established to collect molecular and clinical information of a thousand Chinese colorectal cancer patients. Here, the authors present the genomic landscape of the ChangKang cohort and find a subgroup of patients defined by abnormal mitochondrial copy numbers.
