Frontiers in Pediatrics (Feb 2023)
Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review
- Charlotte Elizabeth Verrall,
- Charlotte Elizabeth Verrall,
- Charlotte Elizabeth Verrall,
- Derek Lee Tran,
- Derek Lee Tran,
- Derek Lee Tran,
- Joseph Yuan-Mou Yang,
- Joseph Yuan-Mou Yang,
- Joseph Yuan-Mou Yang,
- Joseph Yuan-Mou Yang,
- David Revalds Lubans,
- David Revalds Lubans,
- David Revalds Lubans,
- David Scott Winlaw,
- Julian Ayer,
- Julian Ayer,
- David Celermajer,
- David Celermajer,
- David Celermajer,
- Rachael Cordina,
- Rachael Cordina,
- Rachael Cordina,
- Rachael Cordina
Affiliations
- Charlotte Elizabeth Verrall
- Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia
- Charlotte Elizabeth Verrall
- Children’s Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
- Charlotte Elizabeth Verrall
- Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
- Derek Lee Tran
- Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
- Derek Lee Tran
- Central Clinical School, The University of Sydney School of Medicine, Sydney, NSW, Australia
- Derek Lee Tran
- Charles Perkins Centre, Heart Research Institute, Sydney, NSW, Australia
- Joseph Yuan-Mou Yang
- Developmental Imaging, Murdoch Children's Research Institute, Melbourne, VIC, Australia
- Joseph Yuan-Mou Yang
- Neuroscience Research, Murdoch Children's Research Institute, Melbourne, VIC, Australia
- Joseph Yuan-Mou Yang
- Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
- Joseph Yuan-Mou Yang
- Department of Neurosurgery, Neuroscience Advanced Clinical Imaging Service (NACIS), Royal Children's Hospital, Melbourne, VIC, Australia
- David Revalds Lubans
- 0Centre for Active Living and Learning, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia
- David Revalds Lubans
- 1Hunter Medical Research Institute, New Lambton Heights, NSW, Australia
- David Revalds Lubans
- 2Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
- David Scott Winlaw
- 3Cardiothoracic Surgery, the Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
- Julian Ayer
- Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW, Australia
- Julian Ayer
- Children’s Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
- David Celermajer
- Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
- David Celermajer
- Central Clinical School, The University of Sydney School of Medicine, Sydney, NSW, Australia
- David Celermajer
- Charles Perkins Centre, Heart Research Institute, Sydney, NSW, Australia
- Rachael Cordina
- Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
- Rachael Cordina
- Central Clinical School, The University of Sydney School of Medicine, Sydney, NSW, Australia
- Rachael Cordina
- Charles Perkins Centre, Heart Research Institute, Sydney, NSW, Australia
- Rachael Cordina
- 4Heart Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia
- DOI
- https://doi.org/10.3389/fped.2023.1111785
- Journal volume & issue
-
Vol. 11
Abstract
People with a Fontan circulation are at risk of neurodevelopmental delay and disability, and cognitive dysfunction, that has significant implications for academic and occupational attainment, psychosocial functioning, and overall quality of life. Interventions for improving these outcomes are lacking. This review article discusses current intervention practices and explores the evidence supporting exercise as a potential intervention for improving cognitive functioning in people living with a Fontan circulation. Proposed pathophysiological mechanisms underpinning these associations are discussed in the context of Fontan physiology and avenues for future research are recommended.
Keywords
