Capability of hydrogen peroxide to induce oxidative stress and atheromatous lesions in female pregnant rats

Abstract

This study was conducted to determine the capability 0.5% H2O2 on drinking water, for the induction of oxidative stress status in female pregnant rats. Moreover, this study deal with role of this stress in initiation and development of atheromatous lesions via estimation the level of malondialdehyde (MDA) as lipid peroxidation index and Glutathione (GSH) as antioxidant index in aorta, heart and liver tissues as well as the histological examination of the that tissues. The result elucidate study the levels of lipid profile parameters in all studied animal. In addition, the results showed histologizal lesions, represented by localization of fatty vacuoles foam calls in intimal media layers associated with lymphogtic in filtration and proliferation of vascular smooth muscle cells toward the intima, these lesions appear at 21 day from treated H2O2 in female pregnant rats. The study also remark hitopathological changes in placenta.

Keywords

• oxidative stress
• atheromatous
• pregnant
• rats