P101 REFERENCE VALUES OF DIFFERENT PARAMETERS OF VASCULAR FUNCTION IN CAUCASIAN POPULATION WITHOUT CARDIOVASCULAR DISEASES. EVA STUDY

Abstract

Objective: To describe the mean values of different parameters of vascular function, evolution with age and differences by gender in the general population without cardiovascular diseases. Design and method: An observational, descriptive, cross-sectional study. Study population: From the population assigned to the participating healthcare centres, a cluster random sampling stratified by age and gender was performed to obtain 501 participants aged between 35 and 75, 100 per decade, (50% women) without cardio or cerebrovascular disease. Measurements: pulse wave velocity femoral carotid (cfPWV) was determined using the SphygmoCor System, Cardio Anckle Vascular Index (CAVI) and the pulse wave velocity ankle arm (aaPWV) using the VaSera. Results: Mean values: age 55.9 ± 14.2 years (Males = 65.9 ± 14.3y, Females = 55.8 ± 14.2y, p = 0.935); CAVI: 8.0 ± 1.4 (Males = 8.1 ± 1.5, Females = 7.9 ± 1.4, p = 0.043); aaPWV = 12.9 ± 2.7 m/seg (males = 13.2 ± 2.5 m/seg and women = 12.7 ± 2.9 m/seg, p = 0.064) and cfPWV: 6.5 ± 2.0 m/sec (Males = 6.8 ± 2.2 m/sec, Females = 6.2± 1.8 m/sec, p < 0.001). For each year that the age increases, an increase of the CAVI of 0.073 (y=3.919 + (0.073*age)), in males 0.075 (y=3.943 + (0.075*age)) and in women 0.071 (y=3.900 + (0.071*age)). An increase in aaPWV of 0.137 m/sec (y=5.276 m/sec + (0.137 m/sec * age)) , in males 0.118 (y=6.554 m/sec + (0.118 mm*age)) and in women 0.156 (y=3,978 m/sec + (0,156 m/sec*age)) and an increase in cfPWV of 0.092 m/sec (y=1.417 m/sec + (0.092 m/sec*age)), in males 0.104 (y=1.075 m/sec + (0.104 m/sec*age)) and in women 0.080 (y=1.748 m/sec + (0.080 m/sec*age)). Conclusions: The mean values of CAVI and cfPWV as well as the annual increase are greater in males than in females. However, there are no differences in the mean values of the aaPWV and the annual increase is greater in females.