Mechanisms Protecting <i>Acinetobacter baumannii</i> against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment

Abstract

Acinetobacter baumannii is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, A. baumannii was placed on the World Health Organization (WHO) drug-resistant bacteria and antimicrobial resistance research priority list. This review summarizes current studies on mechanisms that protect A. baumannii against multiple stresses caused by the host immune response, outside host environment, and antibiotic treatment. We particularly focus on the ability of A. baumannii to survive long-term desiccation on abiotic surfaces and the population heterogeneity in A. baumannii biofilms. Insight into these protective mechanisms may provide clues for the development of new strategies to fight multidrug resistant strains of A. baumannii.

Keywords

• <i>Acinetobacter baumannii</i>
• biofilm
• desiccation stress
• multidrug resistance
• persisters
• proteostasis