Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results

Abstract

The aim of this work is to develop a completely integrated Lab-On-Chip (LOC) for easy, rapid and cost-effective immunoassays. The pathogen sensing system is composed of a microfluidic channel surrounded by planar microcoils which are responsible for the emission and the detection of magnetic fields. The system allows the detection and quantification of superparamagnetic beads used for immunoassays in a “sandwich” antigen-antibody configuration. Multiphysics simulations have been achieved and preliminary experimental results have allowed to validate the structure.

Keywords

• Lab-on-chip
• magnetic detection
• pathogen sensing
• multiphysics simulations
• diagnostic in vitro device
• microfluidics.