A novel asymmetric amphiphilic porous film of (PLA)-(PLA-b-PEG)-(PEG) with controlled gradual pore size

Ran Huang; Boxin Zhou; Zhuping Nie; Weiwei Ding; Xilin Jiang; Yihu Song

Results in Materials (Jun 2020)

A novel asymmetric amphiphilic porous film of (PLA)-(PLA-b-PEG)-(PEG) with controlled gradual pore size

Ran Huang,
Boxin Zhou,
Zhuping Nie,
Weiwei Ding,
Xilin Jiang,
Yihu Song

Affiliations

Ran Huang: State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; Corresponding author.
Boxin Zhou: Department of Materials Technology and Engineering, Research Institute of Zhejiang University-Taizhou, Taizhou, Zhejiang, 318000, China
Zhuping Nie: Department of Materials Technology and Engineering, Research Institute of Zhejiang University-Taizhou, Taizhou, Zhejiang, 318000, China
Weiwei Ding: Department of Materials Technology and Engineering, Research Institute of Zhejiang University-Taizhou, Taizhou, Zhejiang, 318000, China
Xilin Jiang: Department of Materials Technology and Engineering, Research Institute of Zhejiang University-Taizhou, Taizhou, Zhejiang, 318000, China
Yihu Song: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China; Corresponding author.

Journal volume & issue: Vol. 6
p. 100089

Abstract

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A porous film of (PLA)-(PLA-b-PEG)-(PEG) is fabricated as a general biomedical device for potential applications. For the purpose of providing both mechanic strength and bio-friendly supporting, the film is designed to be asymmetric with a PLA-densed hydrophobic surface and a PEG-densed hydrophilic surface. Beyond the conventional technique to achieve amphiphilicity and porosity via simple blend of two typical biopolymers, a fine controlled processing is developed to achieve the gradual pore size along depth with the attendance of block polymer, which provides several advantages such as avoiding sharp phase separation, the gradual release of biofactors as a carrier, etc.

Published in Results in Materials

ISSN: 2590-048X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/results-in-materials

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