Mantle Cell Lymphoma: Are New Therapies Changing the Standard of Care?

Abstract

The prognosis of mantle cell lymphoma (MCL) has improved rapidly over recent years with the evolution of new management strategies. The disease, once considered fatal, has now become more of a chronic illness, with recurrent relapses that can be managed with a variety of treatment modalities, such as chemoimmunotherapy, stem cell transplantation, and novel targeted therapies. Several treatment options are already available for young, fit patients with newly diagnosed MCL, while many newer agents are being tested in relapsed/refractory MCL. The need for more effective treatment strategies in the elderly population is being addressed by numerous ongoing studies. With the advent of newer treatment modalities with more efficacy and less toxicity, it is now necessary to re-evaluate the way MCL is managed. This paper provides a comprehensive review of emerging, novel agents for the treatment of MCL.

Keywords

• autologous stem cell transplant (asct)
• clinical trials
• mantle cell lymphoma (mcl)
• novel therapy