Nature Communications (Sep 2016)

Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis

  • Robert M. Vogel,
  • Amir Erez,
  • Grégoire Altan-Bonnet

DOI
https://doi.org/10.1038/ncomms12428
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses.