The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

Hale Tunbak; Rocio Enriquez-Gasca; Christopher H. C. Tie; Poppy A. Gould; Petra Mlcochova; Ravindra K. Gupta; Liane Fernandes; James Holt; Annemarthe G. van der Veen; Evangelos Giampazolias; Kathleen H. Burns; Pierre V. Maillard; Helen M. Rowe

doi:10.1038/s41467-020-19170-5

Nature Communications (Nov 2020)

The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s

Hale Tunbak,
Rocio Enriquez-Gasca,
Christopher H. C. Tie,
Poppy A. Gould,
Petra Mlcochova,
Ravindra K. Gupta,
Liane Fernandes,
James Holt,
Annemarthe G. van der Veen,
Evangelos Giampazolias,
Kathleen H. Burns,
Pierre V. Maillard,
Helen M. Rowe

Affiliations

Hale Tunbak: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
Rocio Enriquez-Gasca: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
Christopher H. C. Tie: Infection and Immunity, University College London
Poppy A. Gould: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
Petra Mlcochova: Department of Medicine, University of Cambridge
Ravindra K. Gupta: Department of Medicine, University of Cambridge
Liane Fernandes: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
James Holt: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
Annemarthe G. van der Veen: The Francis Crick Institute
Evangelos Giampazolias: The Francis Crick Institute
Kathleen H. Burns: Department of Pathology, John Hopkins University School of Medicine
Pierre V. Maillard: Centre for Immunobiology, Blizard Institute, Queen Mary University of London
Helen M. Rowe: Centre for Immunobiology, Blizard Institute, Queen Mary University of London

DOI: https://doi.org/10.1038/s41467-020-19170-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The HUSH complex has been implicated in repressing LINE-1 elements. Here the authors reveal that the complex negatively regulates the type I IFN response in human cells through epigenetic regulation of LINE-1 elements

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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