Nature Communications (Oct 2022)
Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
- C. Albert,
- L. Bracaglia,
- A. Koide,
- J. DiRito,
- T. Lysyy,
- L. Harkins,
- C. Edwards,
- O. Richfield,
- J. Grundler,
- K. Zhou,
- E. Denbaum,
- G. Ketavarapu,
- T. Hattori,
- S. Perincheri,
- J. Langford,
- A. Feizi,
- D. Haakinson,
- S. A. Hosgood,
- M. L. Nicholson,
- J. S. Pober,
- W. M. Saltzman,
- S. Koide,
- G. T. Tietjen
Affiliations
- C. Albert
- Department of Biomedical Engineering, Yale University
- L. Bracaglia
- Department of Biomedical Engineering, Yale University
- A. Koide
- Perlmutter Cancer Center, New York University Langone Medical Center
- J. DiRito
- Department of Surgery, Yale University
- T. Lysyy
- Department of Surgery, Yale University
- L. Harkins
- Department of Biomedical Engineering, Yale University
- C. Edwards
- Department of Surgery, Yale University
- O. Richfield
- Department of Biomedical Engineering, Yale University
- J. Grundler
- Department of Biomedical Engineering, Yale University
- K. Zhou
- Department of Molecular Biophysics and Biochemistry, Yale University
- E. Denbaum
- Perlmutter Cancer Center, New York University Langone Medical Center
- G. Ketavarapu
- Perlmutter Cancer Center, New York University Langone Medical Center
- T. Hattori
- Perlmutter Cancer Center, New York University Langone Medical Center
- S. Perincheri
- Department of Pathology, Yale University
- J. Langford
- Department of Surgery, Yale University
- A. Feizi
- Department of Biomedical Engineering, Yale University
- D. Haakinson
- Department of Surgery, Yale University
- S. A. Hosgood
- Department of Surgery, University of Cambridge
- M. L. Nicholson
- Department of Surgery, University of Cambridge
- J. S. Pober
- Department of Immunobiology, Yale University
- W. M. Saltzman
- Department of Biomedical Engineering, Yale University
- S. Koide
- Perlmutter Cancer Center, New York University Langone Medical Center
- G. T. Tietjen
- Department of Biomedical Engineering, Yale University
- DOI
- https://doi.org/10.1038/s41467-022-33490-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Targeted nanoparticle delivery to sites of interest is important for targeted therapeutics. Here, the authors improve the targeting efficiency of antibodies on nanoparticles using a monobody adapter to correctly orientate the antibody to preserve targeting function and demonstrate application in targeting the vascular endothelium of human kidneys.
