Nature Communications (Aug 2018)

Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

  • Dirk Benzinger,
  • Mustafa Khammash

DOI
https://doi.org/10.1038/s41467-018-05882-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.