Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1

Kailun Zhang; Kiara Pankratz; Hau Duong; Matthew Theodore; Jingwen Guan; Anxiao (Andrew) Jiang; Yiruo Lin; Lanying Zeng

doi:10.1128/mBio.01013-21

mBio (Oct 2021)

Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1

Kailun Zhang,
Kiara Pankratz,
Hau Duong,
Matthew Theodore,
Jingwen Guan,
Anxiao (Andrew) Jiang,
Yiruo Lin,
Lanying Zeng

Affiliations

Kailun Zhang: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Kiara Pankratz: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Hau Duong: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Matthew Theodore: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Jingwen Guan: Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Anxiao (Andrew) Jiang: Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA
Yiruo Lin: Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA
Lanying Zeng: ORCiD; Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA

DOI: https://doi.org/10.1128/mBio.01013-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Phage P1 has been shown potentially to play an important role in disseminating antibiotic resistance among bacteria during lysogenization, as evidenced by the prevalence of P1 phage-like elements in animal and human pathogens. In contrast to phage λ, a cell fate decision-making paradigm, P1 lysogenization was shown to be independent of MOI.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal