mBio
(Oct 2021)
Interactions between Viral Regulatory Proteins Ensure an MOI-Independent Probability of Lysogeny during Infection by Bacteriophage P1
Kailun Zhang,
Kiara Pankratz,
Hau Duong,
Matthew Theodore,
Jingwen Guan,
Anxiao (Andrew) Jiang,
Yiruo Lin,
Lanying Zeng
Affiliations
Kailun Zhang
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Kiara Pankratz
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Hau Duong
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Matthew Theodore
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Jingwen Guan
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
Anxiao (Andrew) Jiang
Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA
Yiruo Lin
Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA
Lanying Zeng
ORCiD Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA
DOI
https://doi.org/10.1128/mBio.01013-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Phage P1 has been shown potentially to play an important role in disseminating antibiotic resistance among bacteria during lysogenization, as evidenced by the prevalence of P1 phage-like elements in animal and human pathogens. In contrast to phage λ, a cell fate decision-making paradigm, P1 lysogenization was shown to be independent of MOI.
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