Nature Communications (Nov 2018)

The fluid membrane determines mechanics of erythrocyte extracellular vesicles and is softened in hereditary spherocytosis

  • Daan Vorselen,
  • Susan M. van Dommelen,
  • Raya Sorkin,
  • Melissa C. Piontek,
  • Jürgen Schiller,
  • Sander T. Döpp,
  • Sander A. A. Kooijmans,
  • Brigitte A. van Oirschot,
  • Birgitta A. Versluijs,
  • Marc B. Bierings,
  • Richard van Wijk,
  • Raymond M. Schiffelers,
  • Gijs J. L. Wuite,
  • Wouter H. Roos

DOI
https://doi.org/10.1038/s41467-018-07445-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Red blood cell disorders are often accompanied by increased release of extracellular vesicles (EVs), but their structural and mechanical properties are not fully understood. Here, the authors show that red blood cell EVs show liposome-like mechanical features and are softened in blood disorder patients.