Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

Karolina P. Stepien; Eric A. Prinslow; Josep Rizo

doi:10.1038/s41467-019-12188-4

Nature Communications (Sep 2019)

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP

Karolina P. Stepien,
Eric A. Prinslow,
Josep Rizo

Affiliations

Karolina P. Stepien: Department of Biophysics, University of Texas Southwestern Medical Center
Eric A. Prinslow: Department of Biophysics, University of Texas Southwestern Medical Center
Josep Rizo: Department of Biophysics, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-019-12188-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 18

Abstract

Read online

Munc18-1 and Munc13-1 are key for the exquisite regulation of neurotransmitter release. Here biophysical experiments show how αSNAP inhibits liposome fusion mediated by the neuronal SNAREs and how Munc18-1 overcomes this inhibition, ensuring that release depends on Munc18-1 and Munc13-1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal