The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

Stefano Cavalieri; Paolo Bossi; Gabriele Infante; Rosalba Miceli; Nicola Alessandro Iacovelli; Eliana Ivaldi; Laura Deborah Locati; Cristiana Bergamini; Carlo Resteghini; Imperia Nuzzolese; Salvatore Alfieri; Elena Colombo; Rossana Ingargiola; Marzia Franceschini; Giuseppina Calareso; Lisa Licitra; Ester Orlandi

doi:10.3390/cancers14246170

Cancers (Dec 2022)

The Interplay between Age and Viral Status in EBV-Related Nasopharyngeal and HPV-Related Oropharyngeal Carcinoma Patients

Stefano Cavalieri,
Paolo Bossi,
Gabriele Infante,
Rosalba Miceli,
Nicola Alessandro Iacovelli,
Eliana Ivaldi,
Laura Deborah Locati,
Cristiana Bergamini,
Carlo Resteghini,
Imperia Nuzzolese,
Salvatore Alfieri,
Elena Colombo,
Rossana Ingargiola,
Marzia Franceschini,
Giuseppina Calareso,
Lisa Licitra,
Ester Orlandi

Affiliations

Stefano Cavalieri: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Paolo Bossi: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Gabriele Infante: SSD Clinical Epidemiology and Trial Organization, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Rosalba Miceli: SSD Clinical Epidemiology and Trial Organization, Department of Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Nicola Alessandro Iacovelli: Radiotherapy Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Eliana Ivaldi: Radiotherapy Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Laura Deborah Locati: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Cristiana Bergamini: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Carlo Resteghini: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Imperia Nuzzolese: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Salvatore Alfieri: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Elena Colombo: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Rossana Ingargiola: Radiotherapy Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Marzia Franceschini: Radiotherapy Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Giuseppina Calareso: Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Lisa Licitra: Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Ester Orlandi: Radiotherapy Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy

DOI: https://doi.org/10.3390/cancers14246170
Journal volume & issue: Vol. 14, no. 24
p. 6170

Abstract

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Background. The aim of this work was to analyze the interplay between age and viral status on the outcomes in loco-regionally advanced oropharyngeal and nasopharyngeal cancer patients treated with radiotherapy and different chemotherapy combinations. Methods. A retrospective (2006–2017) analysis was performed on non-metastatic loco-regionally advanced oropharyngeal (both HPV+ and HPV−) and EBV+ nasopharyngeal cancer patients (young: p = 0.395). Conclusions. Several potential age-related (comorbidities, treatment intensity) and disease-related (stage) confounding factors play a prognostic role with differential impacts on both virus and non-virus-related tumors. In HPV+ oropharyngeal cancer and in EBV+ nasopharyngeal cancer patients, age should be considered as the expression of an array of host- and tumor-related features rather than an independent prognostic factor.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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