Transmissible Gastroenteritis Virus: An Update Review and Perspective

Yiwu Chen; Yuanzhu Zhang; Xi Wang; Jian Zhou; Lerong Ma; Jianing Li; Lin Yang; Hongsheng Ouyang; Hongming Yuan; Daxin Pang

doi:10.3390/v15020359

Viruses (Jan 2023)

Transmissible Gastroenteritis Virus: An Update Review and Perspective

Yiwu Chen,
Yuanzhu Zhang,
Xi Wang,
Jian Zhou,
Lerong Ma,
Jianing Li,
Lin Yang,
Hongsheng Ouyang,
Hongming Yuan,
Daxin Pang

Affiliations

Yiwu Chen: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Yuanzhu Zhang: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Xi Wang: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Jian Zhou: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Lerong Ma: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Jianing Li: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Lin Yang: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Hongsheng Ouyang: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Hongming Yuan: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China
Daxin Pang: Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China

DOI: https://doi.org/10.3390/v15020359
Journal volume & issue: Vol. 15, no. 2
p. 359

Abstract

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Transmissible gastroenteritis virus (TGEV) is a member of the alphacoronavirus genus, which has caused huge threats and losses to pig husbandry with a 100% mortality in infected piglets. TGEV is observed to be recombining and evolving unstoppably in recent years, with some of these recombinant strains spreading across species, which makes the detection and prevention of TGEV more complex. This paper reviews and discusses the basic biological properties of TGEV, factors affecting virulence, viral receptors, and the latest research advances in TGEV infection-induced apoptosis and autophagy to improve understanding of the current status of TGEV and related research processes. We also highlight a possible risk of TGEV being zoonotic, which could be evidenced by the detection of CCoV-HuPn-2018 in humans.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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