Nature Communications (Apr 2023)
NAD+ repletion with niacin counteracts cancer cachexia
- Marc Beltrà,
- Noora Pöllänen,
- Claudia Fornelli,
- Kialiina Tonttila,
- Myriam Y. Hsu,
- Sandra Zampieri,
- Lucia Moletta,
- Samantha Corrà,
- Paolo E. Porporato,
- Riikka Kivelä,
- Carlo Viscomi,
- Marco Sandri,
- Juha J. Hulmi,
- Roberta Sartori,
- Eija Pirinen,
- Fabio Penna
Affiliations
- Marc Beltrà
- Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino
- Noora Pöllänen
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki
- Claudia Fornelli
- Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino
- Kialiina Tonttila
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Myriam Y. Hsu
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Sandra Zampieri
- Department of Surgery, Oncology and Gastroenterology, University of Padova
- Lucia Moletta
- Department of Surgery, Oncology and Gastroenterology, University of Padova
- Samantha Corrà
- Veneto Institute of Molecular Medicine
- Paolo E. Porporato
- Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino
- Riikka Kivelä
- Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
- Carlo Viscomi
- Department of Biomedical Sciences, University of Padova
- Marco Sandri
- Department of Biomedical Sciences, University of Padova
- Juha J. Hulmi
- Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University of Jyväskylä
- Roberta Sartori
- Department of Biomedical Sciences, University of Padova
- Eija Pirinen
- Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki
- Fabio Penna
- Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino
- DOI
- https://doi.org/10.1038/s41467-023-37595-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
The loss of nicotinamide adenine dinucleotide is reported to be associated with muscle mitochondrial dysfunction in murine cancer models. Here the authors show that niacin supplementation improves mitochondrial metabolism and reduces muscle wasting in mouse models of cachexia.
