Estimation of quality of life in patients, suffering cardiomyopathy of ischemic genesis, depending on the method of treatment

Abstract

Objective. To estimate the changes of the patients’ quality of life in those, suffering ischemic cardiomyopathy after surgical revascularization and transplantation of the stem cells, obtained from umbilical blood. Materials and methods. There was analysis conducted on changes in quality of life in 113 patients, suffering cardiomyopathy of ischemic genesis. In accordance to the therapeutic method applied, the patients were divided into four groups: first - 38 (33.6%) patients, in whom coronary shunting was conducted, the second - 35 (31.0%) patients, in whom coronary arteries stenting was done, the third - 20 (17.7%) patients, in whom surgical revascularization was added by transplantation of the umbilical blood stem cells; and the fourth - 20 (17.7%) patients, in whom conservative therapy only was administered. Results. Estimation of efficacy of the stem cells, obtained from umbilical blood, was conducted, in accordance to the points quantity reduction, using the data from The Minnesota Living with Heart Failure Questionnaire (MLHFQ), by 50.0% in 12 mo of observation. This enhancement of therapeutic efficacy in aspect of the quality of life improvement after complex application of the myocardium revascularization and transplantation of the umbilical blood stem cells have constituted 75.0%, comparing with conservative therapy, 53.7% - comparing with coronary shunting and 48.6% -comparing with the coronary arteries stenting. There was proved the essential raising of probability for achievement of this effect, as well as a probable cumulative restoration of the chances - 4.85 [2.44 - 964]. In accordance to the SF-36 questionnaire answers data; trustworthily higher indices for the physical and psychological health components were obtained in patients, in whom myocardial revascularization were added by the umbilical blood stem cells. Conclusion. After transplantation of stem cells, obtained from umbilical blood, as the additive to the myocardial revascularization for treatment of ischemic cardiomyopathy, the signs of cardiac insufficiency have diminished, tolerance for any physical loading partly renewed, including solemn round of industry and a self-servicing, as well as the indices for the physical and psychological health improved.

Keywords

• cardiomyopathy; cardiac insufficiency; stem cells from umbilical blood; quality of life