Accelerating innovations in CH activation/functionalization through intricately designed magnetic nanomaterials: From genesis to applicability in liquid/regio/photo catalysis

Abstract

Selective functionalization of highly inert and ubiquitous CH bonds that would provide a ready access to synthetically valuable motifs has perplexed the chemists since long. Also, environmental benignity and economic viability have been the prime factors driving tremendous interest in CH functionalization. This has led to many inspiring discoveries infuriating the development of potent catalytic systems that enable the facile replacement of the CH bonds with conventional functional groups, allowing the construction of C-C, C-N, C-O, C-S, C-B and C-halogen bonds at both sp2 as well as sp3 centres. In fact, catalytic CH functionalization strategies integrating the benefits of magnetic recovery have emerged as sustainable gateway for affording a diverse array of transformations. This review sheds light on the remarkable advancements witnessed in this area as a consequence of integrating the inherent magnetism of catalysts with the cutting-edge direct CH functionalization strategy. Also, the promising future perspectives comprehensively covered in this review is anticipated to motivate the academic and industrial researchers, arousing their creativity for designing competent sustainable strategies to generate a plethora of pharmaceutically active molecules.

Keywords

• Magnetic nanocatalysts
• CH functionalization
• Heterocycles
• Sustainable synthesis
• Magnetic retrievability