Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Yoshinori Tsukumo; Tommy Alain; Bruno D. Fonseca; Robert Nadon; Nahum Sonenberg

doi:10.1038/ncomms11776

Nature Communications (Jun 2016)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3

Yoshinori Tsukumo,
Tommy Alain,
Bruno D. Fonseca,
Robert Nadon,
Nahum Sonenberg

Affiliations

Yoshinori Tsukumo: Department of Biochemistry and Goodman Cancer Research Centre, McGill University
Tommy Alain: Department of Biochemistry, Microbiology and Immunology, Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa
Bruno D. Fonseca: Department of Biochemistry, Microbiology and Immunology, Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa
Robert Nadon: Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University
Nahum Sonenberg: Department of Biochemistry and Goodman Cancer Research Centre, McGill University

DOI: https://doi.org/10.1038/ncomms11776
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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