Lipids in Health and Disease (Sep 2010)

The association between blood glucose and oxidized lipoprotein(a) in healthy young women

  • Yamada Toshiyuki,
  • Uurtuya Shuumarjav,
  • Yamada Shingo,
  • Kotani Kazuhiko,
  • Taniguchi Nobuyuki,
  • Sakurabayashi Ikunosuke

DOI
https://doi.org/10.1186/1476-511X-9-103
Journal volume & issue
Vol. 9, no. 1
p. 103

Abstract

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Abstract Background Oxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose. Methods Several cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years). Results Lp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (β = 0.269, P Conclusions These results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.