Nature Communications (Nov 2017)

Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles

  • Isabel Fernández de Castro Martin,
  • Guillaume Fournier,
  • Martin Sachse,
  • Javier Pizarro-Cerda,
  • Cristina Risco,
  • Nadia Naffakh

DOI
https://doi.org/10.1038/s41467-017-01557-6
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Transport of neo-synthesized influenza A virus viral ribonucleoproteins (vRNPs) from the nucleus to the plasma membrane involves Rab 11 but the mechanism is unclear. Here the authors show that vRNPs are transported through a modified Rab11-positive endoplasmic reticulum and Rab11-dependent vesicles.