Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Hyunji Lee; Seonghyun Lee; Gayoung Baek; Annie Kim; Beum-Chang Kang; Huiyun Seo; Jin-Soo Kim

doi:10.1038/s41467-021-21464-1

Nature Communications (Feb 2021)

Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases

Hyunji Lee,
Seonghyun Lee,
Gayoung Baek,
Annie Kim,
Beum-Chang Kang,
Huiyun Seo,
Jin-Soo Kim

Affiliations

Hyunji Lee: Center for Genome Engineering, Institute for Basic Science
Seonghyun Lee: Center for Genome Engineering, Institute for Basic Science
Gayoung Baek: Center for Genome Engineering, Institute for Basic Science
Annie Kim: Center for Genome Engineering, Institute for Basic Science
Beum-Chang Kang: Center for Genome Engineering, Institute for Basic Science
Huiyun Seo: Center for Genome Engineering, Institute for Basic Science
Jin-Soo Kim: Center for Genome Engineering, Institute for Basic Science

DOI: https://doi.org/10.1038/s41467-021-21464-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 6

Abstract

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Split DddA-derived base editors fused to TALEs enable mitochondrial DNA editing. Here the authors demonstrate their use in mouse embryos with germline transmission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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