Frontiers in Chemistry (Nov 2021)
Diaportones A–C: Three New Metabolites From Endophytic Fungus Diaporthe foeniculina BZM-15
- Fenghua Kang,
- Fenghua Kang,
- Xiuxiang Lu,
- Sha Zhang,
- Sha Zhang,
- Dekun Chen,
- Dekun Chen,
- Min Kuang,
- Min Kuang,
- Weiwei Peng,
- Weiwei Peng,
- Jianbing Tan,
- Jianbing Tan,
- Kangping Xu,
- Kangping Xu,
- Zhenxing Zou,
- Zhenxing Zou,
- Haibo Tan,
- Haibo Tan,
- Haibo Tan
Affiliations
- Fenghua Kang
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Fenghua Kang
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Xiuxiang Lu
- South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- Sha Zhang
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Sha Zhang
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Dekun Chen
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Dekun Chen
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Min Kuang
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Min Kuang
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Weiwei Peng
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Weiwei Peng
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Jianbing Tan
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Jianbing Tan
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Kangping Xu
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Kangping Xu
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Zhenxing Zou
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Zhenxing Zou
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Haibo Tan
- Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China
- Haibo Tan
- Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, China
- Haibo Tan
- South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
- DOI
- https://doi.org/10.3389/fchem.2021.755351
- Journal volume & issue
-
Vol. 9
Abstract
Phytochemical investigation of Diaporthe foeniculina BZM-15 led to one new γ-butyrolactone derivative, diaportone A (1), one cyclopentenone derivative, diaportone B (3), and one monoterpene derivative, diaportone C (5), along with six known compounds (2, 4, and 6–9). Their structures as well as the absolute configurations were characterized by means of NMR, HRESIMS, and ECD spectroscopy and quantum chemistry calculation, respectively. Furthermore, all compounds were evaluated for their cytotoxic activity and antibacterial activity, and compounds 7 and 8 displayed significant antiproliferative effects on three human cancer cell lines (SF-268, MCF-7, and HepG2) with IC50 values ranging from 3.6 to 15.8 μM.
Keywords
- endophytic fungus
- Diaporthe foeniculina
- Leptospermum brachyandrum
- diaportone
- structure elucidation
- cytotoxicity
